Experimental study of diffuse traumatic brain injury on inner ear ultrastructure and auditory function of rats
FU Xing-hua
DENG Yan-li
ZHANG Ping
GU Hong-lan
ZHAO Jun-hui
ZHENG Xue-bin
HAN Li
ZHANG Zai-xing
ZHANG Wen-li
LI Qian
LU He-xiang
SUN Rui-jun
Abstract：Objective To explore the effects of diffuse traumatic brain injury on inner ear ultrastructure and auditory function of rats.Methods Diffuse traumatic brain injury model of rats was established and all 150 rats were randomly divided into control group and experimental groups (including 1-,2-,3-,4-week after injury group)(n =30 in each group).Then auditory brainstem response examination,light microscope and electron microscope technique were used to evaluate the change of hearing function and morphology. The peak latency (PL),the interpeak latency(IPL)were recorded and compared.Results The control group of rats cochlear structures was normal,whereas there were changes of inner ear ultrastructure in the traumatic groups.The threshold values in 1-,2-,3-,4-week after injury group were higher than those in control group [ (18.50±7.83 ),(17.83±8.35 ),(16.00±7.12),(15.42±7.21)dB vs(1.17±2.13)dB] (all P＜0.05).Meanwhile,the PL and IPL in experimental groups were higher than those in control group (all P＜0.05 ).Conclusions Diffuse traumatic brain injury can affect the inner ear ultrastructure and auditory function of rats.The auditory function may be related with the ultrastructure change of inner ear.
Keywords：Diffuse traumatic brain injuryInner earUltrastructureAuditory function
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)