The recent efficacy of compound kusheu injection combined with cisplatin chest perfusion for malignant pleural effussion
YANG Gui-fa
Abstract：Objective To investigate the recent curative and side effects of using compound kushen injection and cisplatin as pleura] infusion for malignant pleura] effusion.Methods Seventy-eight patients who were diagnosed of malignant pleural effusion based on pathology and cytology were divided into two groups randomly.Observation group:compound kushen injection 25 ml +0.9％ sodium chloride injection 40 ml + cisplatin 40-60 ml were injected into thoracic cavity after adequate drainage.Control group:0.9％ sodium chlorideinjection 40 ml +cisplatin 40-60 ml were injected into thoracic cavity after adequate drainage.The curative effects,quality of life and side effects were recorded.Results In the observation group,14 patients were complete remission,19 patients were partial remission and 6 patients had no response.The total response rate was 84.6％ (33/39).In the control group,11 patients were complete remission,12 patients were partial remission and 16 patients had no response.The total response rate was 59.0％ (23/39).The total response rate in the observation group was obviously higher than that in the control group (P＜0.05).The improvement of quality of life in observation group [74.4％ (29/39)]was obviously higher than in the control group [ 46.1％ (18/39)] (P＜0.05 ).The incidence rate of side effects in observation group was much lower than that in the control group (P＜0.05 ).Conclusions For malignant pleural effusion,using compound kushen injection with cisplatin as pleural infusion is better than using cisplatin only.It can also improve the patients'quality of life and prevent the incidence of the side effects.
Keywords：Pleural effusionmalignantDrainage of pleural cavityCompound kushen injectionCisplatin
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)