The application of dexmedetomidine hydrochloride in bronchoscopy
LI Kai-shu
ZHANG Ying
GAO Qiu-ling
LI Yan-yan
LI Chao
WANG Wen
CHANG Gang
Abstract：Objective To evaluate the efficacy and safety of dexmedetomidine hydrochloride in the sedation of bronchoscopy examination.Methods The patients with bronchoscopy examination were divided into two groups:pain-free group and the general group. The patients in the general group received throat local anesthesia with lidocaine and intramuscular injection with diazepam. The pain-free group received intravenous injection with dexmedetomidine hydrochloride 0.5 μg/kg on the basis of throat local anesthesia. The mean arterial pressure (MAP),heart rate (HR),oxygen saturation (SpO2 ),respiratory rate (RR)were observed before,during and after the bronchoscopy examination. The degree of discomfort was compared during the examination and the satisfaction degree was also compared after the examaination.Results The MAP,HR of pain-free group was (88±5)mm Hg,(76±15)min during the examination,while the MAP,HR of general group was (92±4)mm Hg,(80±2)min (P＜0.05 ).The satisfaction of pain-free group was 98％ (49/50)and the satisfaction of general group was 40％ (20/50)(P ＜0.01 ).The pain-free group showed lower discomfort degree and higher satisfaction degree than general group.Conclusion The use of dexmedetomidine hydrochloride in bronchoscopy examination is a safe,effective and comfortable without significant respiratory depression method.
Keywords：BronchoscopyDexmedetomidine hydrochlorideSafetyDegree of satisfaction
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)