Effect of continuous blood purification in the treatment of extrapulmonary acute respiratory distress syndrome
DAI Jing-cun
Abstract：Objective To evaluate the effect of continuous blood purification (CBP)on serum levels of proinflammatory cytokines and clinical outcome in patients with extrapulmonary acute respiratory distress syndrome (ARDS).Methods Forty-six patients with a diagnosis of extrapulmonary ARDS were enrolled and randomized into observation group (n =26 )and control group (n =20 ). The patients in control group received conventional treatment including mechanical ventilation,while patients in observation group were treated with continuous blood purification in addition to the routine treatment.The acute physiology and chronic health evaluation (APACHE)Ⅱ score,oxygenation index,and blood levels of high-sensitivity C-reactive protein (hs-CRP ),interleukin-6 (IL-6 )and tumor necrosis factor alpha (TNF-α )were measured on baseline,day 1 and day 3 after study enrollment.Moreover,duration of mechanical ventilation was also recorded.Results Compared with control group,patients in observation group experienced significant improvement in APACHE Ⅱ score and oxygenation index (P＜0.05 ).Serum levels of hs-CRP,IL-6 and TNF-α decreased more rapidly in patients with observation group (P＜0.05 ).Duration of mechanical ventilation in observation group was much shorter (P＜0.05).Conclusion In patients with extrapulmonary ARDS,continuous blood purification can improve clinical outcome,possibly secondary to removal of pro-inflammatory mediators.
Keywords：Respiratory distress syndromeadultContinuous blood purificationInflammatory mediators
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)