The efficacy of salmeterol/fluticasone propionate combined with montelukast soudium in treatment of cough variant asthma
QI Yu-fei
LIU Shen-hong
WANG Li
Gulinar Adehamu
Abstract：Objective To observe the efficacy of salmeterol/fluticasone propionate combined with montelukast soudium in treatment of adult patients with cough variant asthma.Methods Ninety-three patients were randomly divided into three groups. The observation group inhaled salmeterol/fluticasone propionate (50 μg/250 μg)and took montelukast soudium 10 mg one time for eight weeks.Two other control groups:one inhaled salmeterol/fluticasone propionate (salmeterol/fluticasone propionate group)and the other took montelukast soudium (montelukast soudium group).The improvement of symptom and changes of pulmonary function in three groups were compared.Results After treatment the symptom scores were all lower (P＜0.05 ),the difference was statistically significant among the 3 groups (P＜0.05 ).After 8 weeks of treatment,forced expiratory volume in one second (FEV1 ),FEV1 percentages of predicted (FEV1％ ),peak expiratory flow (PEF)in the observation group,salmeterol/fluticasone propionate group and montelukast soudium group had significant differences (all P＜0.05 );after treatment,FEV1,FEV1％ and PEF in observation group were all higher than those in the salmeterol/fluticasone propionate group and montelukast soudium group,the differences were statistically significant [ FEV:(1.65±0.52)Lvs(1.52±0.63)L,(1.46±0.53)L;FEV1％:(64.41±10.31)％ vs(62.81±11.03)％,(59.02±11.19)％;PEF:(5.24±1.15)L/min vs (6.10±1.28)L/min,(6.62±1.00)L/min,all P＜0.05 ].Conclusion The salmeterol/fluticasone propionate combined with montelukast soudium is superior to the salmeterol / fluticasone propionate or montelukast soudium in treatment of cough variant asthma.
Keywords：Cough variant asthmaSalmeterol/fluticasone propionateMontelukast soudiumPulmonary function
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)