Effect of lansoprazole and mosapride in the treatment of non-erosive gastroesophageal reflux disease
ZHAO Hong
SONG Xiao-hua
XUE Li
ZHANG Hai-ying
ZHANG Dong
MA Xue-zhen
Abstract：Objective To explore the clinical efficacy of lansoprazole combined with mosapride in the treatment of non-erosive gastroesophageal reflux disease (NERD).Methods All 64 cases of NERD were randomly divided into two groups.The observation group was treated with lansoprazole combinedwith mosapride for 8 weeks.The control group was given lansoprazole for 8 weeks.Clinical efficacy and gastroesophageal reflux disease questionnaire (GerdQ)score were compared before and after the treatment.Results In the observation group,significant efficacy was found in 20 cases,efficacy in 7 cases,and inefficacy in 5cases and the total effective rate was 84.4％ (27/32).In the control group,significant efficacy was found in 15 cases,efficacy in 5 cases,and inefficacy in 12 cases,and the total effective rate was 62.5％ (20/32).There was a significant difference of total effective rate between the two groups (P ＜ 0.05).Compared to before treatment,GerdQ sores after treatment in both two groups decreased [observation group:(7.0 ± 2.0)points vs (9.8 ± 2.6)points; control group:(8.2 ± 2.0)points vs (10.3 ± 2.1)points].After treatment for 8 weeks,GerdQ sores in observation group was lower than that in control group (P ＜0.05),Conclusion Combined therapy of lansoprazole and mosapride is effective in the treatment of NERD.
Keywords：Non-erosive gastroesophageal reflux diseaseLansoprazoleMosapride
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)