Identification and transfusion effect evaluation for one rare case of anti-Lea and anti-Leb antibodies combined with autoantibodies
GUO Wen-jing
LIU Yan-ming
Abstract：Objective To study the serological identification method of the Lewis blood system antigens and antibodies and to evaluate the transfusion effectiveness of patients with anti-Lea and anti-Leb antibodies combined with autoantibodies.Methods According to serological theories,we identified the Lewis blood type of the patient using automatic blood/blood compatibility test system.Then we selected the compatible blood and observed the condition of the patient during and after the infusion to evaluate the effectiveness of transfusion.Results The patient was type A blood of the ABO system.The phenotype of Rh system was CCDEe and the phenotype of Lewis system was Le(a + b-).There were not only anti-Lea and anti-Leb antibodies but also autoantibodies in the patient's serum.Infusion of the compatible blood turned out successful.Conclusions Through the antibody screening and antibody identification of the Lewis blood group,screening and infusion of the compatible blood components for patients are observed.The effectiveness of transfusion therapy in refractory anemia patient is poor.However,after appropriate treatments it would be improved.
Keywords：Lewis blood systemAutoantibodiesAntibody screeningBlood transfusion
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)