Preliminary study of embolizing bronchia with fibrin glue and chemical rubber
MA Xin-xin
ZHANG Zhi-tai
MA Xu-chen
ZHANG Shao-yan
LI Dong
SUN Zhen
GUO Lin
Abstract：Objective To study the different effects of bronchial embolization between the fibrin glue and the chemical rubber and the additional role of the trypsin in bronchial embolization.Methods All 30 animals were randomly divided into five groups,including chemical rubber group,fibrin group,trypsin + chemical rubber group,trypsin + fibrin group and trypsin group (n =6 in each group).Embolizing bronchia with chemical rubber and fibrin glue was conducted respectively in chemical rubber group and fibrin group.Pretreating bronchiole with trypsin was done at first,and then the bronchiole was embolized in trypsin + chemical rubber group and trypsin + fibrin group.The embolism was done under the X-ray,then CT scan was used to detected the development of the pulmonary atelectasis.Two weeks after the embolism the animals were killed for lung pathology.Results All of the animals with the chemical rubber had the atelectasis.Only 4 cases of the animals with the fibrin glue appeared short-term atelectasis and all of them recovered in 10 days.The fibrous tissue proliferation could be seen in animals with the trypsin.Conclusions The effect of embolizing bronchia with the fibrin glue is not good enough.The chemical rubber of α- cyanoacrylate alkyl is more preferable.At same time pretreating bronchiole with tryPsin can enhance the embolism and get stable atelectasis.
Keywords：Fibrin glueChemical rubberTrypsinEmbolizing bronchiaBronchoscopic lung volume reduction
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)