Comparison of docetaxel and navelbine in the treatment of elder-patients with advanced non-small cell lung cancer
GUO Cheng-ye
Abstract：Objective To observe the efficacy and toxic of docetaxel and navelbine in treatment of elderpatient with advanced non-small cell lung cancer.Methods Totally 56 elderly patients with advanced non-small cell lung cancer were enrolled.Twenty-nine of them were treated with docetaxel with a dose of 70 mg/m2.Twentyseven of them were treated with navelbine 25 mg/m2.Re-evaluation was done after two cycles.Those who did not get progressed were through another two cycles of chemotherapy and all patients were followed up until disease deteriorated or patient died.Results Docetaxel group complete remission,partial remission,stable degree,progress degree,total efficiency,1 year survival rates were 3.4％ (1/29),24.1％ (7/29),37.9％ (11/29),34.5％ (10/29),27.6％ (8/29)and 24.1％ (7/29).Navelbine group complete remission,partial remission,stable degree,progress degree,total efficiency,1-year survival rates were 0,33.3％ (9/27),37.0％ (10/27),29.6％ (8/27),33.3％ (9/ 27)and 29.6％ (8/27).There was no statistical significance between the two groups(P ＞0.05).The common adverse events were neutropenia,gastrointestinal reactions and oral mucositis,and there was also no statistical significance between the two groups(P ＞ 0.05).But there was a statistical significance on phalacrosis (Ⅲ-Ⅳ)between the two groups (P ＜ 0.05).Conclusions The efficacy of docetaxel and vinorelbine in the treatment of elderly nonsmall cell lung cancer are equally optimistic.Both of them are well tolerated in elderly patients.
Keywords：OcetaxelNavelbineElderly-patients with non-small cell lung cancer
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)