The clinical observation of thoracic cavity drainage with perfusion of cisplatin and combined systemic cbemotherapy in lung cancer with malignant pleural effusion
FEI Xin-xiong
WANG Gang-sheng
HUANG Xu-qun
CHEN Xi
Abstract：Objective To observe the effect and adverse reactions of thoracic cavity drainage with perfusion of cisplatin and combining systemic chemotherapy in lung cancer with malignant pleural effusion.Methods Sixty cases of lung cancer with malignant pleural effusion were treated with thoracic cavity drainage with peffusion of cisplatin and combining systemic chemotherapy.The patients with non-small cell lung cancer were treated with gemcitabine and cisplatin.The patients with small cell lung cancer were treated with etoposide and cisplatin.Results Among the 60 cases,41 cases got complete remission,13 cases got partial remission,4 eases got stable disease and 2cases got progression disease.The complete response rate was 68.3％(41/60) and total curative rate was 90.0％(54/60).After the treatment the half-year survival rate was 95.0％(57/60)and the one-year survival rate was 80.0％(48/60).The main side effects were myelo suppression and gastrointestinal reaction.Conclusions The curative effect is significant through thoracic cavity drainage with perfusion of cisplatin and combining systemic chemotherapy.The adverse effects are tolerable.
Keywords：Lung tumorMalignant pleural effusionGemcitabineEtoposideCisplatinCombined chemotherapy
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)