The incidence and implications of anti-heparin platelet factor 4 antibodies in children with congenital heart disease undergoing Fontan surgery
LI Shu-wen
ZHANG Rui-dong
JIA Qing-yan
LU Jia-kai
OU YANG-chuan
PEN Fa-cheng
CHENG Wei-ping
Abstract：Objective To investigate changes of perioperative anti-heparin platelet factor 4(PF4) antibodies in children with congenital heart disease following Fontan surgery.Methods Ninety-eight patients with American Society of Anesthesiologists(ASA) classification grade Ⅱ-Ⅲ were included in this study.Preoperative and postoperative day 5 and 10 femoral venous blood samples were used to determine the presence of anti-heparin PF4 antibodies with enzyme-linked immunosorbent assay.Platelet counts were measured preoperatively and on postoperative day(POD) 1,POD 3,POD 5,POD 7 and POD 10.Results On POD 5,anti-heparin PF4 antibody IgG was present in 31 of 93 patients(33.3％).On POD 10 anti-heparin PF4 antibody IgG was present in 38 of 91 patients(41.8％).Postoperatively,four patients developed thrombocytopenia and three patients manifested thrombosis.Conclusion Both number of cardiac surgery and previous catheterization history correlate with the rate of anti-heparin/PF4 antibody seroconversion due to prior unfraetionated heparin.
Keywords：Congenital heart diseaseFontan operationHeparinHeparin-induced thromboeytopenia
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)