Impact of tirofiban on myocardial damage and prognosis after pereutaneous coronary intervention in patients with acute myocardial infarction
LIU Jun-wei
ZHAO Wen-jing
Abstract：Objective To explore the effect of tirofiban on myocardial damage and prognosis after pereutaneous coronary intervention(PCI) in patients with acute myoeurdial infarction(AMI).Methods All 120 patients with AMI undergoing PCI were randomly divided into observation group and control group with 60 cases in each group.Serum cardiac troponin T(cTnT),creatine kinase-MB(CK-MB) level on 6 hour and 12 hour after operation,thrombolysis in myocardial infarction(TIMI) on 30 minutes postoperative,occurrence of major adverse cardiac event and echocurdiography index 30 days after operation were compared between two groups.Results Serum cTnT,CK-MB level on 6 hour and 12 hour after operation in observation group were much lower than those in control group [cTnT:(1.54±0.35)g/Lvs(2.16±0.57)g/L,(1.18±0.65)g/Lvs(1.69±0.76)g/L;CK-MB:(32±7)U/L vs(46±8)U/L,(31±6)U/L vs(42±6) U/L,all P＜0.05];occurrence of major adverse cardiac event 30 days after intervention were 1 1.7％(7/60)and 21.7％(13/60) respectively in observation group and control group,with significant differences(P ＜0.05);the patients of TIMI grade 3 on 30 minutes poscoperation in observation group were more than those in control group[ 96.7％(58/60)vs 86.7 ％(52/60) ];compared to control group,left ventricular ejection fraction(LVEF) was higher[(66±9) ％ vs(53±7) ％ ],and left ventriculur end-systolic volume(LVESV) [(30±4) ml vs(38±5) ml ] and left ventriculur end-diastolic volume(LVEDV) [(45±4) ml vs(54±5) ml ] 30 days after treatment in observation group were lower(all P ＜ 0.05).Conclusion Tirofiban administration in patients with AMI before PCI can greatiy decrease myocardial damage and improve reperfusion and patients' prognosis.
Keywords：Acute myocardial infarctionPereutaneous coronary interventionTirofiban
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)