Clinical significance of the concentration changes of plasma D dimer and fibrinogen of patients with chronic obstructive pulmonary disease during acute exaecebation
WANG Gui-qin
LIU Jing-feng
Abstract：Objective To explore clinical significance of the concentration changes of plasma D dimer and fibrinogen of patients with chronic obstructive pulmonary disease(COPD) during the acute and stable phase.Methods Sixty patients with acute exacerbation of chronic obstructive pulmonary disease who underwent conventional treatment plus low molecular weight heparin were enrolled.The level of plasma D dimer and fibrinogen were detected and pulmonary function was monitored during treatment.30 cases among these 60 patients with AECOPD were treated with routine therapy plus low molecular weight heparin( treatment group) and 30 cases without low molecular weight heparin(control group).Results The level of D dimer and fibrinogen of the patients with COPD in acute exaecebation were significantly higher than those in stable phase [ D dimer:( 2.48±1.35 ) mg/L vs ( 0.5 ± 0.25 ) mg/L,t =3.337,P=0.003; fibrinogen:(6.45 ±3.02)g/L vs (2.70 ±2.41)g/L,t =5.647,P=0.017].There were significant difference on FVC,FEV1,FEV1/FVC％ between patients with COPD in acute exaecebation and in stable phase( P ＜0.01 or P ＜ 0.05 ).The course of the disease and the hospitalization expenses of treatment group were significantly decreased than those of control group ( t =2.274,P ＜ 0.05,t =3.727,P ＜ 0.01,respectivly).Conclusion The incidence of venous thromboembolism in patients with AECOPD can be evaluated by detecting the level of D dimer and fibrinogen,and it can also provide reliable basis for application of the haparin in clinical treatment.
Keywords：Chronic obstructive pulmonary diseaseD dimerFibrinogenVenous thromboembolism
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)