Preventive effect of four kinds of hydration therapy on contrast-induced nephropathy in patients undergoing coronary angiography and/or percutaneous coronary intervention
YANG Kun
LIU Wen-xian
EN Wei
Abstract：Objective To observe the preventive effect of application of sodium chloride,sodium bicarbonate,sodium chloride plus N-acetylcysteine (NAC) and sodium bicarbonate plus NAC on contrast agent-induced nephrotoxicity (CIN) in patients undergoing coronary angiography and/or percutanceus coronary intervention ( PCI ).Methods All 627 cases of coronary angiography and/or PCI from October 2010 to October 2011 were randomly divided into four groups:sodium chloride group (n =161 ),sodium bicarbonate group (n =159),sodium chloride plus NAC group (n=157),sodium bicarbonate plus NAC group (n =150).All these patients used the low-osmolar nonionic contrast medium.The incidence of CIN were observed and analyzed.Results Of the 627 patients,28 experienced CIN,and the overall incidence was 4.47％ (28/627).CIN occurred in 4 patients (2.48％ )in the sodium chloride group,7 patients (4.40％) in the sodium bicarbonate group,8 patients (5.10％ ) in the sodium chloride plus NAC group and 9 patients (6.00％ ) in the sodium bicarbonate plus NAC group(P =0.483).Among diabetes complicated with renal insufficiency patients,CIN incidence was not statistically significant in four interventions groups (2/6,3/5,2/7,2/10 respectively,P =0.493).Conclusions Sodium chloride,sodium bicarbonate and NAC for reducing the incidence of CIN have no significant difference.In diabetes mellitus complicated with renal dysfunction,the efficacy of sodium bicarbonate plus NAC in preventing CIN is high but there is no significant difference among four groups.
Keywords：Coronary angiographyPercutaneous coronary interventionContrast-induced nephropathyHydration therapySodium bicarbonateN-acetylcysteine
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)