Genetic polymorphism of methylenetetrahydrofolate reductase in young adults with cerebral infarction
ZHANG Cheng-sen
LIU Cui-wei
PAN Xu-dong
MA Ai-jun
XING Yan
Abstract：Objective To investigate the relation between polymorphisms of N5,N10-methylenetetrahydrofolate reductase(MTHFR) gene and cerebral infarction in young adults.Methods Sixty-seven consecutive young adult cerebral infarction and 71 healthy subjects were enrolled.The polymorphisms of MTHFR gene were analyzed using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results The frequencies of the MTHFR 677genotype were as follows:TT 20 cases(29.8％ ) ;CT 32 cases(47.8％ ) ; CC 15 cases(22.4％ ) in stroke patients and TT 30 cases(42.2％ ) ;CT 24 cases(47.9％ ) ;CC 7 cases(9.9％ ) in normal subjects,respectively.The frequency of T alleles was significantly higher in normal controls than that in stroke patients. The frequencies of the MTHFR 1298 genotype were as follows:AC,43.3％; AA,56.7％ in stroke patients and AC,19.7％ ; AA,80.3％ among normal subjects,respectively.The frequency of C alleles was significantly higher among stroke patients than that among normal controls.Conclusion MTHFR 677 and 1298 polymorphisms are positively associated with risk of cerebral infarction in young adults.
Keywords：Cerebral infarctionMethylenetetrahydrofolate reductasePolymorphism
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)