Clinical study of serum homocysteine in acute coronary syndrome patients and the relationship between the severity of coronary lesions and the levels of serum homocysteine
ZHENG Hong
MI Shu-hua
ZHAO Quan-ming
TIAN Lei
JIA Shu-jie
YANG Hong-xia
Abstract：Objective To explore the levels of serum homocysteine (HCY) and the relationship between the HCY and the severity of coronary lesions in acute coronary syndrome (ACS).Methods Totally 178 patients who were diagnosed of ACS by coronary artery angiography and 65 cases as a normal control group were enrolled.The levels of HCY were detected.The patients with ACS were divided into one-artery lesion group,two-artery lesion group and three-artery lesion group according to the number of coronary artery lesions.The patients with ACS were also divided into Gensini score ＜ 20 group,Gensini score 20-40 group and Gensini score ＞ 40 group by Gensini score of coronary artery lesion.The correlation between the number of coronary artery lesions and serum HCY,the severity of coronary lesions and serum HCY was analyzed.Results Serum level of HCY was significantly higher in patients with ACS than that in normal group [ (20 ± 6) μmol/L vs ( 8 ± 4) μmol/L ] ( P ＜ 0.01 ).Serum level of HCY in three-artery lesion group [ (23 ± 5 )μmol/L] was significantly higher than that in two-artery lesion group [ (21 ±4) umol/L] and one-artery lesion group [ ( 18 ±4) μmol/L],(P ＜0.01 ).Serum level of HCY in Gensini score ＞40 group[ (25 ± 6)μmol/L] was significantly higher than that in Gensini score 20-40 group [( 21 ± 4)μ mol/L] and Gensini score ＜ 20 group [ ( 16 ± 3) μmol/L ],( P ＜ 0.01 ).Conclusions Levels of serum HCY are significantly higher in patients with ACS than those in normal group.Serum HCY is correlated with ACS coronary lesion account and severity of coronary lesions.
Keywords：Acute coronary syndromeHomocysteic acidCoronary angiography
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)