Risk factors of the chronic hepatitis C with liver steatosis
QIU Xiu-xia
LU Wei
ZUO Miao
CHEN Xin
SUN Peng
Abstract：Objective To investigate if retinol binding protein 4 (RBP4) is an important factor in chronic hepatitis C with liver steatosis.Methods Quantitative detection of HCV RNA and genotyping analysis was completed by Fluorescence Quantification- -Polymerase Chain Reaction (FQ-PCR) and Reverse Transcription-Polymerase Chain Reaction( RT-PCR),liver function,triglyceride,cholesterin and insulin resistance index.RBP4 test was completed by Enzyme-Linked Immunosorbnent Assay (ELISA).Data were analyzed by SPSS 11.5.The control group included 42 healthy human.Results Slight histopathologic damage included 22 patients.20 patients had moderate and severe histopathologic damage.Baseline characteristics were significantly different among slight and moderate or severe histopathologic damages.61.9％ of CHC had liver steatosis,28.6％ of CHC with liver steatosis had moderate or severe histopathologic damages.The Body Mass Index( BMI),alanine amiotransferase( ALT),aspartate aminotransferase(AST) and Homeostatic Model Assessment Of Insulin Resistance (HOMA-IR) were higher in steatosis group than in control group( P ＜ 0.01 ).There were no statistic differences in RBP4.RBP4 and HOMAIR were negatively correlated in CHC with steatosis.There was no relation between RBP4 and BMI.Conclusions Live steatosis has important pathological characteristics in CHC with liver steatosis.CHC with liver steatosis is related to IR and BMI.The possibility of serious liver disease in patients with CHC and liver steatosis is higher than that of other patients with CHC.RBP4 is not an important factor in patients with CHC and steatosis.
Keywords：Chronic hepatitis CBody mass indexFluorescence quantification-polymerase chain reactionRetinol binding protein 4Homeostatic model assessment of insulin resistance
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)