Research on the change and correlations of serum thyroid hormone levels in patients with diabetic nephropathy
ZHANG Lin
DU Qun
Abstract：Objective To explore the relationship between the renal function and thyroid function in the patients with diabetic nephropathy.Methods One hundred and thirty-two patients with diabetes mellitus (DM) from December to September 2009 at the Second Affiliated Hospital of Baotou Medical College were selected.40 healthy volunteers from June to September 2010 were selected as controls.4 patients with clinical hyperthyroidism and 2 patients with clinical hypothyroidism were excluded from the 132 subjects included.The remaining 126 patients with DM were divided into groups according to urinary albumin excretion rate (UAER) (examined three times within two weeks) and glomerular filtration rate(GFR) respectively.The differences of free tri-iodothyronine (FT3 ),free thyroxine (FT4 ),and thyroid-stimulating hormone (TSH) levels were compared respectively.Results The more serious diabetic nephropathy was,the lower FT3 level was.Levels of FT3 based on UAER had no statistical differences (P ＞0.05) ; FT of 3GFR,≤ 30 ml/min groupand GFR 31 to 60 ml / min group were lower than that of GFR ≥ 90ml/min group [ (2.53 ± 0.88 ),( 2.63 ± 0.83 ) pmol/L vs ( 3.14 ± 0.64 ) pmol/L,P ＜ 0.05 ] ; levels of FT4 and TSH among all the groups had no statistical differences (P ＞ 0.05).Conclusions The thyroid hormone levels of patients with diabetic nephropathy are reduced in various degrees.Thyroid function of patients who were at the clinical nephropathy stage is likely to be subclinical hypothyroidism as diabetic nephropathy gets worse.
Keywords：Diabetes mellitusDiabetic nephropathyThyroid hormones
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)