Clinical observation of extrapyramidal reactions after treatment with droperidol during gynecologic and obstetric postoperative analgesia
SUN Dong-yan
JIANG Xue-li
MA Tian-rui
ZHAO Xing-mei
FENG Ping
Abstract：Objective To observe the effects of droperidol on postoperative analgesia extrapyramidal reactions in different gynecologic and obstetric surgery,and the safety of clinical drug.Methods Clinical data from 3568 patients of epidural analgesia after gynecologic and obstetric surgery were analyzed.There were 176 cases with ectopic pregnancy surgery,992 cases with cesarean section,392 cases with hysterectomy,256 cases with other gynecologic and obstetric surgery in 1816 cases with postoperative epidural analgesia from June 2007 to June 2008.5mg droperidol were added into 100 ml analgesic solution for treatment.From July 2008 to June 2009,in 1752 patients of epidural analgesia after gynecologic and obstetric surgery,there were 163 cases with ectopic pregnancy surgery,973 cases with cesarean section,357 cases with hysterectomy and 259 cases with other gynecologic and obstetric surgery.In these cases,2.5 mg droperidol were added into 100 ml analgesic solution.Results In 1816 patients treated with 5 mg droperidol,extrapyramidal reactions occurred in 13 cases.The incidence was 0.72％.In 1752 patients treated with 2.5 mg droperidol,no extrapyramidal reactions occurred.There was a significant statistical difference in the incidences of extrapyramidal reactions between the two groups of patients (x2 =12.59,P ＜0.01 ).Among the patients treated with 5 mg droperidol,the incidences of extrapyramidal reactions after the surgery of ectopic pregnancy,cesarean section and hysterectomy were 4.55％,0.30％ and 0％.There were significant differences of the three different surgical procedures (x2 =28.85,P ＜ 0.01 ).Conclusion Extrapyramidal reactions of droperidol in postoperative epidural analgesia are associated with dose,age,medication methods,compatibility and perioperative mental state of patients.
Keywords：Gynecologic and obstetric surgeryDroperidolPostoperative epidural analgesiaExtrapyramidal reactions
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)