Clinical study of patient controlled epidural analgesia using chloroprocaine hydrochloride combined with sufentanil in patients with cesarean section
PENG Zhi-yong
BAI Man-yue
PENG Wei-ping
CHENG Zhi-gang
WANG Yun-jiao
YANG Sheng-hui
Abstract：Objective To study the effects and safety of Chlorpromazine Hydrochloride(CP)or ropivacaine combined with sufentanil for patient controlled epidural analgesia(PCEA) during cesarean section.Methods Sixty patients( ASA Ⅰ ～ Ⅱ )receiving cesarean section were randomly divided into two groups.Postcaesarean section patients with PCEA in group C were given mixture of 1.0％ CP and 0.4 mg/L sufentanil.Postcaesarean section patients with PCEA in group R were given mixture of 0.125％ ropivacaine and 0.4 mg/L sufentanil.The analgesia effects were evaluated by visual analogue scales( VAS) and Bromage scores.The analgesia effects were evaluated by visual analogue scales(VAS) and Bromage scores.Results The analgesia effects were recorded at 4,8,12,24 and 48 hours after caesarean section.There were no respectively significant differences of static VAS scores (4,8,12,24,48hours) between Group C and Group R [ (2.9 ± 0.4) scores vs (2.7 ± 0.6) scores,( 1.8 ± 0.8) scores vs ( 1.8± 0.9) scores,( 1.8 ± 0.5 ) scores vs ( 1.6 ± 0.4) scores,( 1.8 ± 0.5 ) scores vs ( 1.6 ± 0.4) scores,( 1.2 ± 0.6 )scores vs ( 1.1 ± 0.6) scores,( 1.5 ± 0.4) scores vs ( 1.5 ± 0.3 ) scores,P ＞ 0.05 ].Dynamic VAS scores (4,8,12,24,48hours) in group C was respectively similar to that in group R [ (3.9 ± 1.1 ) scores vs (3.7 ± 1.2) scores,(3.2± 0.8) scores vs (3.3 ± 0.9) scores,(2.8 ± 0.5 ) scores vs (2.7 ± 0.6) scores,(2.6 ± 0.4) scores vs ( 2.5 ± 0.6 )scores,(2.0 ± 0.7) scores vs (2.2 ± 0.5 ) scores,P ＞ 0.05 ].No motor function block was reported in any group and the modified Bromage score.was zero.There were no respectively significant differences in sensory block levels (4,8,12,24,48hours) between Group C and Group R [ ( 7.9 ± 0.8 ) scores vs ( 7.7 ± 0.6 ) scores,( 6.7 ± 1.0 )scores vs (6.8 ± 0.9) scores,(6.7 ± 0.8 ) scores vs (6.6 ± 0.7 ) scores,(6.8 ± 0.9) scores vs ( 6.7 ± 0.8 ) scores,(6.6 ± 0.7) scores vs (6.5 ± 0.9 ) scores,P ＞ 0.05 ].Vital signs were stable after operation and the recurrence rates of adverse reactions were relatively low(6.6 percent).Conclusions PCEA with 1.0％ Chlorpromazine combined with 0.4μg/ml sufentanil is safe and effective for patient with cesarean section.
Keywords：AnalgesiaepiduralCesarean sectionChloroprocaine HydrochlorideRopivacaine
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)