The influence on C-reactive protein and the curative effect of edaravone combined ozagrel sodium in treatment of acute cerebral infarction
YE Shi-neng
RUAN Jing
ZHANG Xiao-zhi
Abstract：Objective To observe the influence on C-reactive protein (CRP) and curative effect of edaravone combined ozagrel sodium in treatment of acute cerebral infraction (ACI).Methods Totally 80 patients with ACI were randomly divided into two groups:observation group ( treated with ozagrel sodium plus edaravone) and control groups ( treated with ozagrel sodium).All patients were scored by Clinical Neurologic Functional Defect Scoring (CNFDS),and the clinical effect was measured.Then serum CRP level was measured within 2 hours before and after treatment.Results After treatment,curative effect exhibited significantly better in observation group compared with control group ( total rate of excellence:72.5％ vs 37.5％,the total efficiency:90％ vs 80％,x2 =10.365,P=0.035).The CRP levels were both decreased in these two groups.In observation group the CRP level decreased significantly from (9.64 ± 2.92 ) mg/L to (4.16 ± 1.05 ) mg/L after treatment ( t =2.947,P =0.042 ),and in control group,it decreased significantly from (9.89 ±2.65) mg/L to 6.88 ±0.92) mg/L after treatment(t =1.85,P =0.047 ).Conclusion Combined therapy of edaravone with ozagrel sodium can protect brain tissue through reducing the CRP level.
Keywords：Acute cerebral infractionEdaravoneOzagrel SodiumC-reactive protein
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)