Clinical study of S-adenosyl-L-methionine in the treatment of malignant obstructive jaundice after surgical drainage
LI Hong-bo
DING You-ming
WANG Bin
Abstract：Objective To study the effect of S-adenosyl-L-methionine on the liver functions in patients receiving biliary drainage for malignant obstructive jaundice.Methods Totally 45 cases with malignant obstructive jaundice from Jaunary 2009 to December 2010 were randomized into two groups after undergoing surgical drainage.Control group(20 cases) had normal treatment; study group(25 cases) had additional intravenous infusion of 1000 mg of S-adenosyl-L-methionine per day on the base treatment.Clinical symptoms and liver function were observed.Results Fourteen-day treatment with S-adenosyl-L-methionine could reduce the clinical symptoms.The levels of serum glutamate transaminase,aspartate aminotransferase,glutamyl transpeptidase,total bilirubin,direct bilirubin and alkaline phosphatase were reduced more significantly than those in control group,P ＜ 0.05.Conclusion Applying S-adenosyl-L-methionine to patients with malignant obstructive jaundice after sugical drainage of the biliary tract can improve the clinical symptoms,signs and the decrease of serum bilirubin and liver enzymes.
Keywords：Obstructive jaundiceS-adenosyl-L-methionineBiliary drainageLiver function
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)