Effect and significance of Ki67 expression in neoadjuvant chemotherapy of breast cancer
ZHAO Hui
PANG Ling-yun
Abstract：Objective To study the changes of Ki67 index in breast cancer tissue and to analyze the effect and the significance in neoadjuvant chemotherapy.Methods The expression of the Ki67 before and after neoadjuvant chemotherapy in 81 cases breast cancer patients was examined.The pathological reaction of breast cancer tissues after neoadjuvant chemotherapy was studied.Results The expression of Ki67 had significant changes after neoadjuvant chemotherapy [ high expression:18 cases:56 cases,low expression:63 cases:25 cases,P ＜ 0.05 ].Patients with significant Ki67changes showed good outcomes with neoadjuvant chemotherapy.Conclusion The index of Ki67 can be a guide for drug use of neoadjuvant chemotherapy and it is a strong prognostic molecular marker for judging the curative effect of chemotherapy.
Keywords：Breast neoplasmsNeoadjuvant chemotherapy
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)