Expression of cyclin D1 in breast cancer
YANG Lan
WANG Lei
WANG Xu-fen
Abstract：Objective To investigate the expression of eyclin D1 in the specimen of breast cancer and its correlation with pathologic staging,metastases of lymph nodes,estrogen receptor and anti-oncogene p53 in breast cancer.To reveal the relationship between the expression of cyclin D1 and the generation,development,prognosis of breast cancer.Methods The expression of cyclin D1,estrogen receptor(ER) and P53 was detected through elivision plus immunohistochemical staining method in the breast cancer,and the results were analyzed with correlative clinical information.Results The expression of cyclin D1 was high in breast cancer.It intimately correlated with the metastases of lymph nodes and the expression of estrogen receptor and anti-oncogene p53.Conclusions The expression of cyclin D1 is associated with the generation and development of breast cancer.Separate effect may exist between cyclin D1 and estrogen receptor.Through possible interaction cyclin D1 and anti-oncogene p53 participate together in the generation of breast cancer.Cyclin D1 may become a new predictor marker in the treatment of breast cancer.
Keywords：Breast neoplasmsCyclin D1Immunohistochemistry
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)