Effects of Xuebijing combined with high doses of methylprednisolone on acute paraquat poisoning
WANG Guang-qian
LIU Si-guan
Abstract：Objective To evaluate the effects of Xuebijing combined with high doses of methylprednisolone on the treatment of acute paraquat poisoning.Methods Totally 50 patients with acute paraquat poisoning were admitted to our hospital from August 2007 to March 2010 and were divided into test group and control group.Patients in control group were treated with routine therapy.Test group accepted Xuebijing combined with high doses of methylprednisolone which substituted dexamethasone on the basis of control group.Results The oxygen pressure,zymologic indexes and blood creatinine in test group were significantly different from those in control group [ ALT:( 86 ±11 ) U/L vs ( 135 ± 10 ) U/L; AST:( 265 ± 85 ) U/L vs (543 ± 130) U/L; TBil:( 8 ± 5 ) μmol/L vs ( 17 ± 5 ) μmol/L;Cr:(260 ± 110) μmol/L vs (532 ± 185) μmol/L;PaO2:(77 ± 13) vs (60 ± 23) ;P ＜ 0.05 ].The mortality of test group was lower than that of control group [ 34.6％ (9/26) vs 66.7％ (16/24) ; P ＜ 0.05 ].Conclusion At the early stage,Xuebijing combined with high doses of methylprednisolone can protect major organs from paraquat injury and reduce the mortality of paraquat poisoning.
Keywords：ParaquatPoisoningXuebijingMethylprednisolone
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)