The effects of rosuvastatin on regulating blood lipid level and inflammation factor levels in diabetes patient with hyperlipidemia
WANG Zhe
LIU Fen
L(U) Zu-ying
GUAN Ren-lian
Abstract：Objective To observe the effects of rosuvastatin on regulating blood lipid level and serum inflammation factor levels in diabetes patient with hyperlipidemia,including interleukin-6 (IL-6),tumor necrosis factor alpha (TNF-α) and C-creactive protein(CRP).Methods Forty-two cases of type 2 diabetes patients with hyperlipidemia were given rosuvastatin 10mg each night for 4 weeks.Levels of blood lipid,IL-6,CRP and TNF-α were detected before and after treatment.Results After treatment with rosuvastatin,the serum TC,TG,LDL-C,were significantly decreased [ (4.3 ± 1.8 ) mol/L vs (6.2 ± 2.0) mol/L; ( 1.5 ± 0.8 ) mol/L vs (2.4 ± 1.3 ) mol/L; (2.3± 0.8) mol/L vs (3.2 ± 0.8) mol/L,all P ＜ 0.05 ],and the serum levels of IL-6,TNF-α and CRP were significantly decreased[ (27.2 ± 12.6) μg/L vs (60.5 ±20.3) μg/L; (0.21 ±0.15) μg/L vs (0.32 ±0.09) μg/L;(4.91 ±0.13)mg/L vs (5.87 ±0.21 )mg/L,all P ＜0.05].Conclusion Rosuvastatin can significantly decrease the levels of blood lipid and serum Inflammation Factor in diabetes patient with hyperlipidemia.
Keywords：RosuvastatinDiabetes mellitusHyperlipidemiaInflammation Factor
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)