Assessment of the efficacy and safety of oxiracetam capsules and nimodipine for patients with vascular dementia
YI Yong-shang
HAN Xu-dong
WANG Shuai
SUN Qi-dong
ZHANG Qin-ling
Abstract：Objective To evaluate the clinical efficacy and safety of oxiracetam capsules and nimodipine in patients with vascular dementia by taking.Methods One hundred and twenty patients with vascular dementia were randomly divided into treatment group:oxiracetam group and nimodipine group.Before treatment and 6 months after treatment,Mini-Mental State Examination (MMSE) and Activities of Daily living scale (ADL) were used to assess the therapeutic effect.Results MMSE and ADL scores of 3 groups after treatment were all significantly improved ( P ＜ 0.05).After treatment,the MMSE scores in combined treatment group and nimodipine group had a significant difference [ (20.8 ± 4.2)scores vs ( 17.4 ± 3.2)scores,P ＜ 0.01 ] ; the difference in oxiracetam group and nimodipine group was statistically significant[ ( 19.7 ± 4.7) scores vs ( 17.4 ± 3.2) scores,P ＜ 0.05 ] ; after the treatment,ADL score in combined treatment group,nimodipine group and oxiracetam group difference had statistical significances [ (58.2 ± 1.6) scores vs (53.3 ± 11.2) scores,(55.3 ± 4.2) scores,P ＜ 0.01 or P ＜ 0.05 ].Conclusion Compared with taking nimodipine,patients with vascular dementia who take oxiracetam capsules and nimodipine can significantly improve mental retardation and living skills.
Keywords：Vascular dementiaOxiracetam capsuleNimodipine
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)