Clinic analysis of treatment of the acute ischemic stroke with indobufen
YANG Kun
SUN Jia-fan
Abstract：Objective To investigate the effects and safety of Xinbei- indobufen in patients with acute ischemic stroke disease.Methods A totally of 170 patients with acute ischemic stroke were selected and randomly divided into experiment group ( n =82) and control group ( n =88 ).The patients in experiment group were given anti-platelet indobufen and others in control group were given aspirin for 6 weeks.Platelet aggregation,the score of neurology impairment and adverse effects were compared between the two groups.Results After treatment,the platelet aggregation in both groups was lower at 2-week and 6-weeks than before (P ＜ 0.01 ).The score of neurology impairment in the both groups was improved at the 6-weeks ( P ＜ 0.01 ).There were no significant differences in the platelet aggregation and the score between experiment group and control group (P ＞ 0.05 ).Drug related serious adverse effects were not found in the experiment group.Conclusions Indobufen may reduce significantly platelet aggregation among the patients with acute ischemic stroke.The effect on anti-platelet of indobufen is equal to one of aspirin.Indobufen related adverse effects are seldom and minor.Indobufen is safe in treating acute ischemic stroke.
Keywords：Acute ischemic strokeIndobufenAnti-platelet
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)