The efficacy observation of torasemide and frusemide in treatment of cadiorenal syndrome

YANG Xiao-hong; ZHENG Xiao-hui; HAO Zeng-guang

doi:10.3760/cma.j.issn.1673-4777.2012.01.017

Abstract：Objective To observe the efficacy of torasemide and frusemide in the treatment of cadiorenal syndrome.Methods Sixty heart failure patients with renal dysfunction on admission were divided into creatinine level [ (40 cases),Ⅱ (20 cases) and were also randomly divided into torasemide group and furosemide group.Based on the conventional treatment,torasemide group were given torasemide 20 mg/d intravenously and furosemide group were given furosemide intravenous injection of 40 mg/d.Before and after the administration of drugs,the level of serum potassium,sodium,calcium,creatinine levels were determined and every 24 h urine volume were recorded.The symptoms,the changes of heart function and the incidence of adverse reactions of the two groups were observed.Results Average urine volume of different admission creatinine levels in torasemide group was significantly higher than that in the furosemide group [ ( 1685 ± 49 )ml vs (1442 ± 38 )ml,(1042 ± 32)ml vs (968 ± 38 )ml,P ＜0.05 ] ; improvement rate of heart function in torasemide group with creatinine levels stage I were higher than that in the furosemide group.The serum potassium in torasemide group increased significantly than that in furosemide group [ ( + 0.03 ± 0.01 )mmol/L vs (-0.01 ± 0.01 )mmol/L,P ＜ 0.05] with a smaller blood creatinine fluctuation range ( P ＜ 0.05 ).The swelling rate had no significant differences between the two groups ( P ＞ 0.05 ) ; cardiac function improvement rate and serum potassium changes in patients with creatinine level Ⅱ level had no significant differences between the two groups (P ＞0.05 ).The incidence of adverse reactions in the torasemide group was 6.7％ (2/30) and 30.0％ (9/30) in the furosemide group ( P ＜ 0.0l ).Conclusion In the treatment of cadiorenal syndrome,torasemide is more effective and safe than frusemide.