The association among brain natriuretic peptide, high sensitive c-reative protein and leptein (a) in patient with acute coronary syndrome
GAI Yan-hong
LUAN Xiao-dong
ZHANG Rui-jun
XU Dan
Abstract：Objective To measure serum B-type natriuretic peptide (BNP),high-sensitive C-reactive protein( hs-CRP)and leptein (a) concentration in patients with acute coronary syndrome,stable angina pectoris and normal healthy subjects ; to investigate the correlation of between BNP and acute coronary syndrome.Methods One hundred and ninety subjects were divided into four groups: 36 patients with acute myocardial infarction (AMI group),38 patients with unstable angina pectoris(UAPgroup) ; 30 patients with stable angina pectoris( SAP group)and 30 normal healthy subjects as the control group.Serum BNP concentration was determined by enzyme linked immuno-asorbent assay Echocardiography was performed in all patients with coronary artery disease to detect left ventricular ejection fraction (LEVF),left ventricular volume parameters and to evaluate ventricular wall-motion.Results The level of serum BNP concentration was high in patients with AMI group (391 ± 136)ng/l and UAPgroup (267 ±80)ng/l than that with SAP group (36 ±21 )mg/L and control group ( 1.0 ±0.4) mg/L,P ＜0.05,respectively.The level of serum concentration hs-CRP was higher in patients with AMI group ( 16 ± 15 ) mg/L and UAPgroup ( 11 ± 7 ) mg/L than that with SAP group (2 ± 1 ) mg/L and control group ( 1.0 ± 0.4 ) mg/L,P ＜ 0.05.The serum level of Lp(a) was higher in UAPgroup (324 ± 171 )mg/L and AMI group (367 ± 191 ) mg/L patients than that in SAP group ( 191 ± 130 ) mg/L patients and control group patients ( 150 ± 116 ) mg/L ( P ＜ 0.01 ).Serum BNP concentration was positively correlated with hs-CRP and Lp(a) (r =0.53,0.54 P ＜0.01 ) and negatively correlated with LVEF.Conclusion The reason of increased serum BNP concentration is not only corrected with the LVEF,but also with the reaction of acute inflamation due to coronary ischemia.
Keywords：Acute coronary syndromeNatriuretic eptide brainHigh sensitive C-reactive proteinLeptein(a)
Publication Date：2012-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)