Clinical effect of valsartan, atorvastatin combined with amiodarone on patients with paroxysmal atrial fibrillation to maintain sinus rhythm

LI Jian-ming; ZHANG Hai-yan; ZHANG Jie; SHI Zhong-liang; ZHANG Yi; JIANG Xu-feng; ZHENG Dong-fang; WEI Hua

doi:10.3760/cma.j.issn.1673-4777.2012.01.004

Abstract：Objective To evaluate the clinical effect of valsartan,atorvastatin combined with amiodarone on patients with paroxysmal atrial fibrillation to maintain sinus rhythm.Methods One hundred and twenty patients with paroxysmal atrial fibrillation were chosen and divided into treatment group (68 cases) and control group (52 cases).After all patients recovered sinus rhythm via taking amiodarone orally or intravenous injection or electrical conversion.The control group took 600 mg of amiodarone orally each day in the first week,400 mg per day in the second week,200 mg per day in the third week and maintained 200 mg per day afterwards.The treatment group used additional 80 mg of valsartan each day and 10 mg of atorvastatin calcium capsule every night.The maintenance ratio of sinus rhythm of the two groups of patients after three,six,nine and twdve months of treatment was observed.Results After three months of treatment,the maintenance ratio of sinus rhythm of treatment group and control group were 91.2％ (62/68) and 86.5％ (45/52) respectively.The difference between the two groups had no statistical significance(P ＞0.05).After six,nine and twelve months of treatment,the maintenance ratio (％) of sinus rhythm of treatment group/control group was 86.8％ (59/68),85.3％ (58/68),82.4％ (56/68) ; 71.2％ (37/52),65.4％ ( 34/52 ),59.6％ ( 31/52 ),respectively.The differences had statistical significance ( P ＜ 0.05).Conclusion The curative effect of valsartan,atorvastatin combined with amiodarone on the patients with paroxysmal atrial fibrillation to maintain sinus rhythm is better than that of the treatment with only amiodarone.