Analysis of clinical value of hybrid capture 2 high-risk hunan papillonavirus DNA and its dose
LI Da-hai
Mayinuer · Niyazi
Abstract：Objective To analyze clinical value of high risk human papillomavirus (HR-HPV) dose-effect in cervix tested by hybrid capture 2(HC2) and determine the relationship between HR-HPV virus load and cervical lesion.Methods From August 2009 to May 2010,2851women accepted HR-HPV test by HC2,with or without cytological test by TCT.All women with HR-HPV positive or abnormalities in cytology were taken cervical biopsy under the colposcopy.Results The diagnosis of histopathology were cervicitis in 648 cases,cervical intraepithelial neoplasia(CIN) Ⅰ 150 in cases,CIN Ⅱ 43 in cases,CIN Ⅲ 64 in cases and cervical cancer(CC) 119 in cases.The rate of HR-HPV infection was 17.7％ (438/2475) in healthy women and cervicitis,84.0％ ( 126/150 ) in CIN Ⅰ,76.7％ (33/43)in CINⅡ,81.3％ (52/64) in CINⅢ,90.8％ ( 108/119)in CC (P ＜0.05).The viral loads of HR-HPV DNA were 223.60 ±476.55 in cervicitis,448.38 ±758.86 in CIN Ⅰ,890.41±1036.29 in CIN Ⅱ,and 608.36 ±683.98 in CIN Ⅲ,1047.84 ± 1008.43 in CC ( P ＜ 0.05 ).Conclusion The viral loads of HR-HPV DNA have no correlation with the grade of cervical precancerous lesions,but the possibility of high-grade cervical intraepithelial neoplasia is higher with more viral loads.HC2 has a certain application value in screening and follow up of patients with cervical precancerous lesions or cervical cancer.
Keywords：Cervical interaepithelial neoplasiaHuman papillomavirusViral loadHybrid capture 2
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)