The expression and clinical significance of amplified in breast cancer 1 protein in thyroid tumor tissues
GUO Hai-peng
LIU Mu-yuan
PENG Han-wei
HONG Chao-qun
ZHANG Hao
Abstract：Objective To investigate the expression and clinical significance of amplified in breast cancer 1 ( AIB1 ) protein in thyroid tumor.Methods Immunohistochemistry was used to detect the expressions of AIB1 in 97 cases of thyroid carcinoma,32 cases of thyroid adenoma and 16 cases normal tissues,then the correlation between expression and clinical features,including histological type,and lymphatic metastasis was analyze.Results Compared with the normal tissues( 2/16,12.50％ ),the positive rates of AIB1 expressions were higher in thyroid carcinoma ( 81/97,83.51％ ) and thyroid adenoma ( 20/32,62.50％ ) ( P ＜ 0.001 ) and were the highest in thyroid carcinoma.There was a significant difference of AIB1 expressions between thyroid carcinoma and thyroid adenoma(x2 = 6.247,P ＜0.012).For thyroid carcinoma,the expression of AIB1 was correlated with lymphatic metastasis (x2 = 7.222,P ＜ 0.027 ),however,it was not correlated with histological type (x2 = 1.340,P = 0.512 ).Conclusion The over expression o f AIB1 may be involved in the carcinogenesis and development of thyroid carcinoma.
Keywords：Amplified in breast cancer 1Thyroid tumorExpression
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)