The protective effects of daisaikoto on alcohol-induced gastric mucosal damage
GU Su-fang
NI Run-zhou
JI Xi-lin
XIAO Ming-bing
JIANG Feng
WEI Qun
Abstract：Objective To study the protective effects of daisaikoto and its components on alcohol-induced gastric mucosal injury and to explore the mechanism.Methods Sixty-six male Sprague Dawley rats were randomly divided into 11 groups with 6 rats in each group,namely control group,model group and 9 therapeutic groups ( groups of daisaikoto,bupleurum,baicalin,zhishi,banxia,rhubarb,paeony,ginger,jujube).The rats in control group and model group were given 2 ml of normal saline intragastrically; rats in other groups were given 2 ml of different solutions of above drugs respectively.Two hours later,rats in control group were given 1 ml of normal saline and other groups were given 1 ml of absolute alcohol intragastrically.After 2 hours,all rats were sacrificed and gastric mucusal injury index and injury inhibition rates were calculated.Pathological changes in gastric mucosa were observed after HE stain.superoxide dismutase (SOD) and Maleic dialdehyde ( MDA)were measured in gastric homogenate.Results The gastric mucosa in control group was intact and the tissue structure was orderly arranged.There are mucous hemorrahge and necrosis in model group.The mucous changes in groups of bupleurum,banxia,rhubarb and paeony were similar to those in model group.The mucosal injury was mild in the groups of daisaikoto,baicalin,zhishi,ginger,jujube,with no significant difference from control group.SOD significantly decreased while MDA increased in model group (P ＜ 0.05 ).Daisaikoto,baicalin,zhishi,ginger,jujube can antagonize the decrease of SOD and the increase of MDA.Conclusions Daisaikoto efficiently antagonizes alcohol-induced gastric mucosal injury.Its components of baicalin,zhishi,ginger and jujube have the similar effects.Daisaikoto and its effective components protect gastric mucosa from alcohol-induced injury possibly through the effects of oxidation resistance.
Keywords：DaisaikotoGastric mucosa damageMaleic dialdehydeSuperoxide dismutase
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)