Clinical significance of NT-proBNP and cardiac troponin in acute exacerbation of chronic obstructive pulmo nary disease patients
YAN Xin-yan
WANG Guang
JIANG Yu
WANG Yin
LU Ya-li
YANG Lin-xing
Abstract：Objective To study the change and the singifiance of N-terminal pro-B natriuretic peptide (NT-proBNP) and cardiac tropnin-I( cTnI )in the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients with respiratory failure.Methods Totolly 80 hospitalized AECOPD patients were divided into the pure AECOPD group and the AECOPD with respiratory failure group,N-terminal pro-brain and TnI was measured by using electrochem inescence law and the difference was compared finally.Results N-terminal pro-brain and TnI in the AECOPD with respiratory failure group was higher than that in the pure AECOPD group( P ＜ 0.05 ),N-terminal pro-brain levels were positively correlated with pulmonary arterial systolic pressure ( r = 0.75,P ＜ 0.05 ) and cTnI ( r =0.65,P ＜ 0.05 ),N-terminal pro-brain levels were negatively correlated with PaO2 ( r = -0.73,P ＜ 0.05 ).Conclusion Deteming the level of N-terminal pro-brain and cTnI can be helpful of judging the severity degree and prognosis in AECOPD.
Keywords：Acute exacerbation of chronic obstructive pulmonary diseaseN-terminal pro-brainCardiac tropnin-I
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)