The influence of type A aortic dissection on coagulation function
HE Liang
GUO Sheng
DU Yu-kui
Abstract：Objective To explore the changes of blood coagulation function and clinical significances in type A aortic dissection (AD).Methods One hundred and fourteen patients with type A aortic dissection group and 95 persons in healthy control group were selected respectively(NC).Analysis of international normalized ratio (INR),activated partial thromboplastin time (APTT ),thrombin time(TT ),fibrinogen (FIB)and D-dimer (DD)were conducted.Results INR,APTT,FIB,DD in AD group significiantly increased compared with NC group [ (1.11,3.86 ±1.87,37.62 ±8.43,5.78 ±6.63) ;(1.02,2.45 ±0.74,32.39 ±36.44,0.14 ±0.12)],TT decreased respectively[ 15.70 ; 19.75 ] ( P ＜ 0.01 ).Subact and chronic aortic dissection showed a significant increase in FIB[ (5.04 ± 1.84) vs ( 3.29 ± 1.61 ) ],decrease in DD compared with acute group [ ( 2.21 ± 1.67 ) vs (6.67 ±7.12) ],P ＜0.01.Conclusion AD is characterized by activation of both coagulation and fibrinolysis,together with inhibition of fibrino lysis,resulting in an imbalance between coagulation and fibrinolysis leading to a hypercoagulation state.
Keywords：Aortic dissectionCoagulationFibrinolysis
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)