The pathogens of bacterial and fungal keratitis and their resistance to antibiotics
HE Mei-feng
WU Wei
ZHOU Jia-hao
TANG Xi-lan
Abstract：Objective To analyze the distribution and shifting trends of pathogens causing bacterial or fungal keratitis and their resistance to commonly used antibiotics in Zhongshan ophthalmic center.Methods Two thousend and forty-six specimens from patients with infective keratitis from January 2004 to December 2010 were collected.Bacterial and fungal culture-positive rate,the genus distribution of isolates and resistance regularity to antibiotics were analyzed retrospectively.Results Out of 2046 specimens,1022 were positive cultures,showing a positive rate of 49.9％.Of those individuals with positive cultures,463 had pure bacterial infection ( including 11 specimens with two bacterial growth),500 had pure fungal infection and 59 had mixed growth.The predominant bacterial pathogens isolated were Gram-positive cocci ( 336 of 533,63.0％ ) and Gram-negative bacilli ( 163 of 533,30.6％ ),in which Staphylococcus epi(257 of 533,48.2％ )was the most common pathogen,followed by Pseudomonas aeruginosa(84 of 533,15.76％ ).The predominant fungal pathogens isolated was Fusarium.Spp.( 180 of 559,32.2％ ),followed by Aspergillus Spp.(139 of 559,24.9％ )and Helminthosporium( 110 of 559,19.7％ ).The distribution of pathogens causing bacterial keratitis had no significant change.However,there has been an increase in Helminthosporium and a decrease in Aspergillus Spp.Overall,aminoglycosides showed better sensitivity to Staphylococcus epi,and fluoroquinolones had a better sensitivity to Pseudomonas aeruginosa.Conclusions In the area of Guangdong,the most common pathogens of bacterial keratitis was Staphylococcus epi,which showing highest sensitivity to neomycin,and Fusarium Spp are the predominant pathogens of fungal keratitis.The increased recovery of Helminthosporium and decreased recovery of Aspergillus Spp.from keratitis isolates presents an important challenge to the ophthalmology.
Keywords：KeratitisBacterial infectionFungal infectionPathogenDurg resistance
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)