Pharmacokinetics and bioequicalence of torasemide capsules and injection in healthy people
ZHOU Lai-ji
Abstract：Objective To study the pharmacokinetics and bioequivalence of torasemide capsules and injection in healthy volunteers.Methods A single oral dose of 10 mg of torasemide capsules or injection was given to 24healthy volunteers in a randomized two-period crossover study.high-performance liquid chromatography (HPLC) was performed to detect torasemide.Results The main pharmacokinetic parameters of torasemide capsules and injection were as follows:peak concentration(Cmax)was (1123 ± 104) and (1362 ±258) μg/L; peak time(tmax)was (1.2 ±0.3) and (1.0 ±0.3)h;t1/2 was (4.1 ±1.0) and (4.0±1.0)h; area under concentration-time curve(AUC)0-twas (3583 ±365)and (3844 ±362) μg/(h · L) ;AUC0-∞ was (3838 ±482)and (3999 ±463) μg/(h · L).The relative bioavailability of capsules was (97.0 ± 20.5) ％.Conclusion Torasemide capsules and injection are bioequivalent in healthy volunteers.
Keywords：Chromatographyhigh pressure liquidTorasemideBiological availability
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)