Application of procalcitonln window asa switching point for sequential invasive to noninvasive ventilation in treatment of severe respiratory failure of chronic obstructive pulmonary disease
ZHU Jian-bo
MA Jian-lin
LIU Xiao-ying
WANG Ai-qin
WANG Xin-an
Abstract：Objective To evaluate the feasibility and the efficacy of early extubation and sequential noninvasive mechanical ventilation (MV) switched by procalcitonin window ( PTC window) in chronic obstructive pulmonary disease with exacerbated hyercapnic respiratory failurel.Methods All selected acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients with respiratory failure were randomly divided into two groups.Sequential MV group by PIC window were the control group (22 cases),and others (23 cases) were as the experimental group underwent sequential MV by PTC window.The invasive MV duration,days of invasive MV,ventilatorassociated pneumonia ( VAP),days of antibiotic exposure,6-month rate of acute exacerbation and 6-month mortality were measured.Results Compared with sequential MV group by PIC window,sequential MV group by PTC window had shorter duration of invasive MV[(3.8 ± 1.4),(6.5 ± 1.8) d,P =0.000 ],fewer days in ICU[(6.9 ±1.7),( 9.6 ± 1.9) d,P =0.000 ],and fewer days of antibiotic exposure.The 6-month rate of acute exacerbation and 6-month mortality were not significantly different compared to the control group[( 21.7％,22.7％,P =1.000) ; (17.4％,13.6,P=0.450) ].Conclusion Early extubation followed by non-invasive MV initiated at the point of PTC window may decrease the duration of invasive MV and reduce antibiotic prescription.
Keywords：Pulmonary diseasechronic obstructiveAcute exacerbationPositive pressure respirationVentilator weaningProcalcitonin
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)