Relationship between depression and health-related quality of life in patients with chronic obstructive pulmonary disease

ZHANG Xiang-feng; WANG Zeng-zhi; GAO Yuan-ming; LIU Shuang

doi:10.3760/cma.j.issn.1673-4777.2011.11.019

Abstract：Objectives To determine the prevalence of depression and examine its impact on the health-related quality of life (HRQoL) among patients with chronic obstructive pulmonary disease (COPD).Methods A total of 65 COPD patients completed the St.George respiratory questionnaire ( SGRQ),Medical outcomes short form-36 (SF-36) and Hamilton depression inventory (HAMD).Results The prevalence of depression was 26.2％.The SGRQ total[(53.3 ± 27.6) vs (38.6 ± 19.4),P ＜ 0.001 ],activity[(57.7 ± 24.4) vs (39.8 ±18.5),P=0.038]and impact[(43.5 ±18.9) vs (33.9±13.7),P=0.042]subscores were significantly worse in the patients with depression.The physical functioning[(26.9 ± 14.4) vs (51.1 ± 10.8),P =0.024],role physical[( 8.33 ± 1.4) vs (26.6 ± 11.7),P =0.003 ],social functioning[( 17.9 ± 7.5) vs (33.3 ± 14.5),P =0.039],rele emotion[(23.8±8.8) vs (41.7 ±19.2),P=0.037]and mental health[(23.8 ±8.0) vs (37.4±11.4),P =0.043]dimensions from the SF-36 were statistically poor in the patients with depression.The patients with severe and very severe lung function defects showed significantly worse total[( 37.8 ± 15.7) vs ( 58.6 ±20.4),P=0.029],activity[(37.8 ±16.4) vs (59.2 ±21.6),P=0.033]and impact[(31.7±8.2) vs (45.6±17.8 ),P =0.043]scores of the SGRQ and significantly poor physical functioning[(27.0 ± 12.9) vs (57.5 ± 29.7),P=0.018],relephysical[(6.0±2.7) vs (33.0 ±13.9),P=0.007],general health[(55.1 ±24.8) vs (76.6 ± 19.4),P =0.048 ],social functioning[( 10.3 ± 2.8) vs (41.1 ± 16.8),P =0.017]and mental health [(24.6 ± 6.6) vs (40.6 ± 1.6),P =0.031]scores on the SF-36.Conclusion The prevalence of depression in COPD patients is considerable,and depression has a negative impact on the HRQoL among COPD patients.