A study on the test of heart rate turbulence and serum carbohydrate antigen125 levels in chronic congestive heart failure and its clinical significance
XU Xin-na
SUN Hua-yi
ZHAO Xing-shan
LI Wen-bin
Abstract：Objective To study the changes and clinical significance of heart rate turbulence (HRT) and serum carbohydrate antigen(CA125) levels in patients with chronic heart failure.Methods 24 h holter ECG recording,echocardiography and level of CA125 were examined in 82 patients with heart failure(HF) and 36 in the comparison group.Turbulence onset(TO) and turbulence slope (TS) were calculated from Holter recordings.The mean value of TO,TS and CA125 between the two groups were compared; TO,TS and serum CA125 levels in different New York Heart Association Classifications were also compared; the relativity between TO,TS,CA125 and LVEF was analyzed as well.Results TO is significantly higher in the HF group compared with the comparison group[( -0.31 ±0.07)％ vs ( -1.31 ±0.13)％,P=0.008) ],TS in the HF group is significantly lower[(2.05 ±0.21) ms/R-R vs (7.76 ± 1.86)ms/R-R,P=0.0006)],and CA125 levels are significantly higher[(80.2 ±9.8 ) U/ml vs (21.3 ± 5.3 ) U/ml,P =0.006) ].The difference of HRT and serum CA 125 levels for patients in different NYHA classification is significant.TO,TS and CA125 levels are significantly related to LVEF.Conclusion The existence of heart rate turbulence is significantly impaired in patients with chronic heart failure and serum CA125 levels of patients with HF rise as well which reflects well the severity of HF.
Keywords：Chronic heart failureHeart rate turbulenceCarbohydrate antigen 125
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)