Clopidogrei's impact on adverse cardiac events of unstable angina patients with different levels of high-sensitivity C-reactive proteins

WANG Chao-zheng; WANG Ke-zhi

doi:10.3760/cma.j.issn.1673-4777.2011.11.015

Abstract：Objective To appraise clopidogrel's impact on adverse cardiac events of unstable angina patients with different levels of high-sensitivity C-reactive proteins(hs-CRP).Methods One hundred and seventy-six cases of unstable angina patients were divided into two groups according to the levels of hs-CRP:group A( hs-CRP ＜2.87 mg/L,86 cases),group B(hs-CRP≥2.87mg/L,90 cases).Group A were randomly divided into group A1(control group,42 cases) and group A2 (observation group,44 cases),and group B were divided into group B1 (control group,44 cases) and group B2( observation group,46 cases)at the same way.The patients of control groups adopted common treatment with aspirin etal,otherwise,the patients of observation groups were given clopidogrel 75 mg,qd besides common treatment.After a year,group A1's incidence rates of the main cardiovascular events、cardiovascular deaths、acute myocardial infarctions、target vessel re-establishments and strokes were compared with group A2 's respectively,and group B1 's compared with group B2's also.Results Incidence rates of group A1 and group A2 's main cardiovascular events、cardiovascular deaths、acute myocardial infarctions、target vessel re-establishments and strokes are alike respectively (P ＞ 0.05 ) ; incidence rates of group B1 and group B2 's cardiovascular deaths,acute myocardial infarctions、target vessel re-establishments and strokes did not reach statistical difference ( P ＞0.05 ),but their incidence rates of main cardiovascular events are different ( P ＜ 0.05 ).Conclusions Clopidogrel can reduce incidence rate of unstable angina patients' main cardiovascular events in a year who have elevated baseline level of hs-CRP,but can't reduce incidence rate of unstable angina patients' main cardiovascular events in a year who have normal base-line level of hs-CRP.