Effect of penehyclidine on inflammatory cell factor during cardiopulmonary bypass in coronary artery by pass graft
LI Gang
CUI Li-fang
LI Chang-zhong
SUN Hong
Abstract：Objective To study the changes of inflammatory cell factor during and after cardiopulmonary bypass (CPB) and clinical effect of penehyclidine hydrochloride injection used in coronary artery bypass graft (CABG).Methods Totally 39 patients receiving CABG were divided into penehyclidine hydrochloride injection group 1,penehyclidine hydrochloride injection group 2 and control group.Before the operation,penehyclidine hydrochloride injection group 1 and penehyclidine hydrochloride injection group 2 were given 0.02-0.03mg/kg of intramuscular injection of penehyclidine.Then 24 hours and 48 hours after the operation,penehyclidine hydrochloride injection group 2 was given 0.02-0.03mg/kg of intramuscular injection of penehyclidine hydrochloride injection respectively.Thirty minutes before the operation,control group received 0.01mg/kg of intramuscular injection of atropin.Body temperature and heart rate of the patients of three groups before and 30 minutes after the injection were observed.The artery blood was picked separately before the anaesthesia induction,30 min after CPB,instantly after the operation,24 hours and 48 hours after the operation.The density of tumor necrosis factor Alpha (TNF-α),the Interleukin 6 (IL-6) and Interleukin 8 (IL-8) by using monoclone antibody enzyme-linked immunosorbent assay (ELISA) were observed.Incidence rate of X sternum pneumonia,support time of breathing machine and resident time in ICU after the operation were analyzed.Results Thirty min after the injection,Heart rate of patients of control group increased,which was higher than that of penehyclidine hydrochloride injection group 1 and penehyclidine hydrechloride injection group 2.After CPB,the density of inflammatory cell factor of patients from control groups all went up clearly compared with that before the anaesthesia induction,reaching the highest when CPB was done,going down gradually after the operation.24 and 48 hours after the operation it was remaining higher than that before the operation[TNF-a:(12.2 ±2.1)ng/L vs (19.4±l.7)ng/L,(26.3 ±2.5)ng/L,(19.1 ±1.7)ng/L,(16.3±1.3) ng/L,P ＜ 0.05 ].The highest levels of penehyclidine hydrochloride injection group 1 and penehyclidine hydrochloride injection group 2 were lower than those of control Group significantly.After the operation,the support time of breathing machine and the resident time in ICU of penehyclidine hydrochloride injection group 1 and Penehyclidine hydrochloride injection group 2 were lower than those of control group significantly[( 10.6 ± 3.7) h,(9.6 ±7.7)h vs (11.8 ±7.7)h; (3.5 ±l.9)h,(3.0±1.8)h vs (3.9 ±1.8)h,P＜0.05].Conclusion Penehyclidine hydrochloride injection controls the release of TNF-α,IL-6 and IL-8 of inflammatory cell factor,relieves pneumonia after CPB and shortens the mechanical airing time in CPU.
Keywords：Coronary artery bypass graftPenrhyclidine hydrochlorideInflammatory cell factorCardiopulmonary bypass
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)