Association between ambulatory pulse pressure, pulse wave veocity, ankle brachial index and carotid intim-media thickness in elderly patients with essential hypertension
XU Ya-fen
LI Xian-liang
CAO Rui-hong
Abstract：Objective To investigate the association between ambulatory pulse pressure(24 h mPP),pulse wave veocity( PWV),ankle brachial index(ABI) and carotid intima-media thickness(IMT) in elderly patients with essential hypertension (EH).Methods Ninety elderly patients with EH were divided into 2 groups according to the 24 h mPP:group A (24 h mPP ≥ 60 mm Hg,n =45 ),greup B ( 24 h mPP ＜ 60 mm Hg,n =45 ).The PWV and ABI were measured by the VP-1000 fully automated analyzer,The IMT was measured by using ultrasonic diagneser (HD1S100SONO-CT).The association between 24 h mPP,baPWV,ABI and IMT was analyzed.Results The 24 h mPP in group A was (65.4 ±6.6)mm Hg and was (51.3 ±5.0) mm Hg in group B.The PWV in group A was significantly higher than that in group B ( P ＜ 0.05 ),The ABI in group A was significantly less than that in group B ( P ＜ 0.05 ),and the IMT in group A was significantly higher than that in group B ( P ＜ 0.05).Linear correlation analysis showed 24 h mPP and baPWV was positively sssociated with IMT (r =0.461,P＜0.01 ; r =0.402,P＜0.01),ABI was negatively associated with IMT (r=-0.267,P＜0.05).Multiple stepwise regression analysis showed 24 h mPP,GLU,baPWV the main factors affecting the IMT.Conclusions In elderly patients with EH,24 h mPP,baPWV,ABI and GLU are related to the development of carotid atheresclerosis and monitoring 24 h mPP,PWV and ABI can predict early atherosclerosis.Early prevention and treatment of atherosclerosis can reduce the incidence of cardiovascular events.
Keywords：HypertensionElderlyAmbulatory pulse pressurePulse wave velocityAnkle-brachial indexCarotid intima-media thickness
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)