Analysis of therapeutic effect of trimetazidine combined with L-carnitine on unstable angina in elderly
LI Xia
YANG Hai-chen
LI Xia
XU Pei-jing
Abstract：Objective To compare the therapeutic effect of trimetazidine combined with L-carnitine on unstable angina in elderly.Methods Totally 85 cases of elderly patients with unstable angina were randomly divided into four groups which included control group,trimetazidine group,L-carnitine group and combined treatment group.The control group received routine treatment.Other groups were respectively treated with trimetazidine,L-carnitine and both of them on the basis of the routine treatment.The therapeutic period was 14 days.Before and after the treatment,we observed the improvement of angina and changes of Electrocardiograph(ECG) and Dynamic Electrocardiography(DCG).Results The angina improved significantly more in the three treatment groups than in the control group.In the aspect of ECG and DCG,the treatment groups improved significantly more in the three treatment groups than in the control group in NST,ΣST and TIB.Compared to the control group,the differences were statistically significant among Trimetazidine group ( P ＜ 0.05 ),L-carnitine group ( P ＜ 0.05 ) and trimetazidine combined L-carnitine group ( P ＜ 0.01 ).The combined treatment group had better effect than single treatment group.There were no adverse reactions in the two drugs.Conclusions Treatment with trimetazidine or L-carnitine can improve the therapeutic effect in elderly with unstable angina on the basis of the routine treatment.Combined treatment of the two drugs has optimistic effect with less adverse accidents.
Keywords：AnginaunstableElderlyTrimetazidineL-carnitineTherapeutic effect
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)