Effect of Tirofiban hydrochloride on coronary perfusion and cardiac function in patients with acute myocardial infarction underwent elective percutaneous coronary intervention
WEI Fang
WEN Shu-feng
ZHAO Jiao-jiao
JIANG Qi
MA Xiao-fing
Abstract：Objective To observe the effect of tirofiban hydrochloride on coronary perfusion,platelet aggression ratio and prognosis in patients with acute ST-elevation myocardial infarction (STEMI) undergoing elective percutaneous coronary intervention (PCI).Methods Fifty-six patients with acute STEMI who underwent elective PCI were randomized to the tirofiban group and the control group.Thrombolysis in myocardial infarction(TIMI) flow grade,the TIMI myocardial perfusion grade (TMPG),platelet aggression ratio,the levels of soluble intercellular adhesion molecule ( sICAM-1 ),heart wall motion score index (WMSI),bleeding rate and the risk for major adverse cardiac events (MACE) were observed.Results The TIMI flow grade before PCI,TMPG before and after PCI in patients of tirofiban group were higher than those in the control group.The slCAM-I levels of tirofiban group after 24 h and 72 h were much lower than these in control group.The rate of MACE and WMSI of tirofiban group[10.7％(3/28) and ( 1.20 ± 0.22)]were lower than those of the control group[35.7％ ( 10/28 ) and ( 1.35 ± 0.26)]( all P ＜ 0.05).Conclusion Tirofiban is associated with reinforced antiplatelet treatment improved target artery patency,myocardial perfusion as well as cardiac function among patients with STEMI undergoing elective PCI.
Keywords：Acute myocardial infarctionPercutaneous coronary interventionTirofibanPrognosis
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)