Clinical significance of circulating T regulatory cell detection in patients with chronic hepatitis B infection
WU Xiao-fei
WANG Hua-yu
YANG Ai-ping
ZHOU Bao-qin
TANG Wei
Abstract：Objective To investigate the clinical value of circulating T regulatory cell (Treg) in patients with chronic hepatitis B (CHB). Methods The circulating Treg frequency and the levels of HBV replication in 48 patients with CHB, including 10 HBV carriers, 18 CHB, and 20 liver cirrhosis ( LC), were analyzed by fluorescence-activated cell sorting (FACS) and by real-time Polymerase Chain Reaction ( PCR), respectively. Results Tregs frequency was (11.59 ±4.34)％ (P ＜0.05) in LC and significantly higher than that in CHB (8.56 ±3.12) ％ or in HBV carries (6.72 ± 2.60)％. HBV DNA copies was 1.7 × 106 copies/ml (P ＜ 0.01 ) in HBV carriers and significantly higher than that in CHB (4.3 × 105 ) copies/ml or in LC (6.8 × 104 ) copies/ml. Significant relationship was found between Treg frequency and HBV DNA copies. Conclusions Circulating Treg would play an important role in CHB infection with correlated closely with the viral replication.
Keywords：Chronic hepatitis BHepatitis B virusRegulatory T-lymphocytes
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)