The relationship between efficacy of PEG-interferon and HLA-DRB1 alleles in the patients with chronic hepatitis B

WANG Xiao-bin; WEN Zi-rong

doi:10.3760/cma.j.issn.1673-4777.2011.10.021

Abstract：Objective To study the relationship between efficacy of PEG-interferon α-2a for forty-eight weeks and some HLA alleles ( HLA-DRB1 ) in the patients with chronic viral hepatitis B from Qingdao of the Hannationality, and provide immuno-genetic knowledge for the prevention and cure of hepatitis B virus infection.Methods Forty patients with chronic viral hepatitis B in a Qingdao population of the Han nationality were subjected to a standard course of treatment with PEG-interferon α-2a for 48 weeks. HLA-DRB1 * 04, * 07 were detected by using the polymerase chain reaction-sequence specific primer (PCR-SSP) technique. The data were analyzed by SC2000 software. Results After forty patients with chronic viral hepatitis B were subjected to a course of treatment with PEG-interferon α-2a for 48 weeks, there were nineteen patients in the complete-responders, ten patients in the partial-responders and eleven patients in non-responders. The patients of HLA-DRB1 * 04 in eleven non-responders were four and in twenty-nine partial-or complete-responders was one. The frequency of HLA-DRB1 * 04 in non-responders was higher than that in the partial-or complete-responders (P ＜0.05 ,OR = 16.0). The patients of HLADRB1 * 07 in eleven non-responders were seven and in twenty-nine partial-or complete-responders were six. The frequency of HLA-DRB1 * 07 in non-responders was higher than that in the partial-or complete-responders ( P ＜ 0.05,OR =6.7 ). Conclusions In a Qingdao population of the Han nationality, no response of PEG-interferon α-2a therapy in the patients with chronic viral hepatitis B was correlated positively with HLA-DRB1 * 04, * 07.