The role of Ginsenoside Rg3 on apoptosis and the levels of transformin growth factor-β1 in A549 cell line
LIU He
LIU Ting
PEI Fu-yang
CONG Duo
Abstract：Objective To investigate the role of ginsenoside Rg3 inducing apotosis in lung A549 cell line and the expression of transformin growth factor( TGF)-β1 levels. Methods Rg3-induced group and the control group were included in this study. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) was used to determine the effect of Rg3 on apoptosis. The expression of TGF-β1 was analyzed by Enzyme-linked Immunosorbent Assay(ELISA). Results MTT assay showed that compared with the control group the apoptosis of Rg3-treated cells dramatically increased. Compared to the control group, the expression of TGF-β1 in the Rg3-treated decreased obviously. Conclusion Ginsenoside Rg3 has a high inhibition in the expression of TGF-β1 in A549 cell line and can induce the apotosis.
Keywords：Ginsenoside Rg3Transformin growth factor-β1Lung cancer A549 cell
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)