Clinical study of intracoronary injections of tirofiban during primary percutaneous coronary intervention in patients with acute myocardial infaction
ZHU Yong-biao
ZHANG Ying
CHEN Xin-tao
Abstract：Objective To evaluate the effect of intracoronary injection of tirofiban on thrombolysis in myocardial infarction (TIMI) flow of infarct-related artery ( IRA ) in patients with acute myocardial infaction ( AMI )during emergency percutaneous coronary intervention (PCI). Methods Totally 98 STEMI patients were divided into tirofiban group (n =46) and routine group (n =52). The TIMI grade and corrected TIMI frame count(CTFC)following PCI operation were compared, and the bleeding condition as well as major adverse cardiac events ( MACE,including death, re-infarction and target vessel revascularization) in hospital and 6 months after discharge from hospital. Results There was a higher percentage of TIMI Ⅲ flow in tirofiban group following PCI (44/46,95.6％ vs 43/52,82.7％, P ＜0.05), and fewer TIMI frames as compared to the routine group (19.8 ± 8.6 frames vs 28.3 ±5.8 frames,P ＜ 0.01 ); The left ventricular ejection fraction (LVEF) one week after PCI was higher in tirofiban group(54.2 ±6.7％ vs 49.6 ±8.1％ ) ( P ＜0. 01 ) ; There was a higher prevalence in the complication of bleeding in tirofiban group but the difference had no statistical significance ( P ＞ 0.05 ). There was significant difference between the two groups in the occurrence of MACE within 6 month follow-up (2/46,4.35％ vs 9/52,17.30％ )(P ＜0.05). Conclusion Intracoronary injection of tirofiban during PCI in the intervention therapy for AMI can improve postoperative TIMI of IRA and myocardial perfusion as well as the clinical prognosis.
Keywords：Myocardial infarctionTirofibanPercutaneous coronary intervention
Publication Date：2011-01-01
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)